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A BBC hospital drama, 'Holby City' began life as a spin-off of the long-running 'Casualty' in 1999.

'Holby City' has always had a very strong cast, and regulars have included the likes of Robert Powell, Hugh Quarshie, Denis Lawson, George Irving, Art Malik, Jane Asher, Sharon Maughan, Tom Chambers, Paul Bradley, Tina Hobley, Adrian Edmondson, Stella Gonet, Michael French, Patsy Kensit, and Ronald Pickup. David Soul also appeared in two episodes as Alan Fletcher.

- Paul Rance/

Holby City Main Cast List (actors/actresses who have appeared in 40 episodes or more - up to January 1st, 2009)

Hugh Quarshie as Ric Griffin (207 episodes, 2001-2008)
Jaye Jacobs as Donna Jackson (172 episodes, 2004-2008)
Tina Hobley as Chrissie Williams (166 episodes, 2001-2008)
Amanda Mealing as Connie Beauchamp (166 episodes, 2001-2008)
Robert Powell as Mark Williams (134 episodes, 2005-2008)
Patricia Potter as Diane Lloyd (121 episodes, 2002-2007)
Paul Bradley as Elliot Hope (114 episodes, 2005-2008)
Luke Roberts as Joseph Byrne (112 episodes, 2005-2008)
Sharon D. Clarke as Lola Griffin (109 episodes, 2003-2008)
Rosie Marcel as Jac Naylor (105 episodes, 2004-2008)
Rakie Ayola as Kyla Tyson (103 episodes, 2003-2008)
Tom Chambers as Sam Strachan (101 episodes, 2006-2008)
Sharon Maughan as Tricia Williams (89 episodes, 2003-2006)
Phoebe Thomas as Maria Kendall (85 episodes, 2003-2008)
Verona Joseph as Jess Griffin (84 episodes, 2002-2007)
Ian Aspinall as Mubbs Hussein (80 episodes, 2001-2005)
Nadine Lewington as Maddy Young (79 episodes, 2007-2008)
Mark Moraghan as Owen Davis (75 episodes, 2001-2005)
Art Malik as Zubin Khan (74 episodes, 2003-2005)
Luisa Bradshaw-White as Lisa Fox (73 episodes, 2001-2005)
Andrew Lewis as Paul Rose (73 episodes, 2000-2008)
Patsy Kensit as Faye Morton (66 episodes, 2007-2008)
Kelly Adams as Mickie Hendrie (65 episodes, 2004-2006)
Hari Dhillon as Michael Spence (55 episodes, 2001-2008)
Alex MacQueen as Dr. Keith Greene (50 episodes, 2005-2008)
Stella Gonet as Jayne Grayson (45 episodes, 2007-2008)
Adrian Edmondson as Percy 'Abra' Durant (45 episodes, 2005-2008)
Peter Wingfield as Dan Clifford (44 episodes, 2006-2008)
Duncan Pow as Linden Cullen (42 episodes, 2008)
Jan Pearson as Kath Fox (42 episodes, 1999-2004)
Kim Vithana as Rosie Sattar (42 episodes, 2003-2005)
Michael French as Nick Jordan (40 episodes, 1999-2006)

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